This sheet provides answers for the Match Game student sheet.
|1. Sickle cell disease||S. The most common inherited blood disorder in the United States|
|2. Sickle cell anemia||B. A common form of sickle cell disease, in which hemoglobin S replaces both beta-globin subunits in hemoglobin|
|3. Sickle||T. The shape of red blood cells created by abnormal versions of beta-globin; these cells have shorter lifespans than normal red blood cells. Their shape and rigidity can cause them to get caught in small blood cells, which can damage organs and trigger acute pain.|
|4. Hemoglobin||R. The molecule in red blood cells that delivers oxygen to cells throughout the body|
|5. The gene involved in sickle cell disease||K. Hemoglobin-Beta gene (the “hemoglobin” gene) found on chromosome 11|
|6. Alpha-globin and beta-globin||P. Subunits of hemoglobin|
|7. Hemoglobin S||F. An abnormal version of beta-globin, which can distort red blood cells into a sickle, or crescent, shape|
|8. Beta thalassemia||A. A blood disorder caused by an unusually low level of beta-globin; this results from another kind of abnormality in the HBB hemoglobin gene|
|9. Inheritance pattern of sickle cell disease||G. Autosomal recessive (the disease presents when a mutated gene is inherited from both parents)|
|10. Signs and symptoms of sickle cell disease||L. Low number of red blood cells (anemia), repeated infections, and periodic episodes of pain|
|11. Anemia||E. A shortage of red blood cells, which can cause shortness of breath, fatigue, and delayed growth and development in children|
|12. Medical interventions for sickle cell disease (pick 5 answers from Column B)||
N. Newborn screening and early identification of the disease
M. Medications (e.g., penicillin in newborns and infants to avoid infection; folic acid supplements to build new red blood cells)
U. Treatment with hydroxyurea, a type of hemoglobin that helps prevent the "sickling" of red blood cells
H. Blood transfusions that provide a patient with healthy red blood cells
I. Bone marrow transplant for people with severe sickle cell disease.
D. A person with one mutation for sickle-cell disease (this person is not affected by the disease but can pass the gene for the disease to his or her children).
|14. 25 percent||
Q. The chance that a child of parents who both carry the mutation for sickle cell disease will be born with the disease.
B. A disease caused by a parasite that is transmitted to a person when they are bitten by an infected mosquito.
|16. Possible genetic explanation for evolution of malaria||
J. Carriers of a mutation in the beta-subunit of hemoglobin are more resistant to malaria.
|17. People most likely to be affected by sickle cell disease||
O. People whose ancestors lived in Africa, India, the Caribbean, the Middle East, and the Mediterranean