Match Game: Genes and Sickle Cell Disease

Match Game: Genes and Sickle Cell Disease Photo Credit: Clipart.com


Complete this quiz using Web resources listed on your Who Gets Sick? student esheet. Write the letter of the definition that corresponds to the word.

Term Definition
  1. Sickle cell disease
  2. Sickle cell anemia
  3. Sickle
  4. Hemoglobin
  5. The gene involved in sickle cell disease
  6. Alpha-globin and beta-globin
  7. Hemoglobin S
  8. Beta thalassemia
  9. Inheritance pattern of sickle cell disease
  10. Signs and symptoms of sickle cell disease
  11. Anemia
  12. Medical interventions for sickle cell disease (pick 5 answers from Column B)
  13. Carrier
  14. 25 percent
  15. Malaria
  16. Possible genetic explanation for evolution of malaria
  17. People most likely to be affected by  sickle cell disease

A.  A blood disorder caused by an unusually low level of beta-globin; this results from another kind of abnormality in the HBB hemoglobin gene

B.  A common form of sickle cell disease, in which hemoglobin S replaces both beta-globin subunits in hemoglobin

C.  A disease caused by a parasite that is transmitted to a person when they are bitten by an infected mosquito.

D.  A person with one mutation for sickle-cell disease (this person is not affected by the disease but can pass the gene for the disease to his or her children)

E.  A shortage of red blood cells, which can cause shortness of breath, fatigue, and delayed growth and development in children

F.  An abnormal version of beta-globin, which can distort red blood cells into a sickle, or crescent, shape

G.  Autosomal recessive (the disease presents when a mutated gene is inherited from both parents)

H.  Blood transfusions that provide a patient with healthy red blood cells

I.  Bone marrow transplant for people with severe sickle cell disease.

J.  Carriers of a mutation in the beta-subunit of hemoglobin are more resistant to malaria.

K.  Hemoglobin-Beta gene (the “hemoglobin” gene) found on chromosome 11

L.  Low number of red blood cells (anemia), repeated infections, and periodic episodes of pain

M.  Medications (e.g., penicillin in newborns and infants to avoid infection; folic acid supplements to build new red blood cells)

N.  Newborn screening and early identification of the disease

O.  People whose ancestors lived in Africa, India, the Caribbean, the Middle East, and the Mediterranean

P.  Subunits of hemoglobin

Q.  The chance that a child of parents who both carry the mutation for sickle cell disease will be born with the disease.

R.  The molecule in red blood cells that delivers oxygen to cells throughout the body

S.  The most common inherited blood disorder in the United States

T.  The shape of red blood cells created by abnormal versions of beta-globin; these cells have shorter lifespans than normal red blood cells. Their shape and rigidity can cause them to get caught in small blood cells, which can damage organs and trigger acute pain.

U.  Treatment with hydroxyurea, a type of hemoglobin that helps prevent the "sickling" of red blood cells

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