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Acid Stomach

Acid Stomach

Introduction

Medical knowledge has come a long way since the days when physicians would use bleeding to cure someone. This growth has been fueled by some basic scientific discoveries, like how micoorganisms can cause many diseases and how the body feels pain. In addition to these discoveries, there have been many advances in health technology that have made it possible for humans to live longer, healthier lives. The activities in this lesson will help you explore the advances in scientists’ understanding of how aspirin works and how understanding it's interaction with other chemicals in the body aided doctors in medical research.


Exploration

Read the article Aspirin Effect: Pain Relief and More that describes the history and science of aspirin (the article starts on page 3 of the PDF). Answer these questions as you read the article. You can record your answers to the questions on the Aspirin Article student sheet. Be sure to save your answers to these questions because you will revisit them later in the lesson.

  • What do willow tree bark extract, oil of wintergreen, and aspirin have in common?
  • The study of the chemistry of medicinal plants began in the 1800s. Why would it have been difficult to identify the active ingredients in those plants?
  • What were some of the drawbacks to salicylic acid as a pain reliever?
  • Felix Hoffman, who worked for the Bayer Company, invented aspirin in 1897. How did he make it?
  • What are some of the benefits of aspirin?
  • How does aspirin work?
  • What do you think are some possible strategies for reducing stomach irritation caused by aspirin?
  • What are some other medical discoveries that have been found as a result of our understanding of how aspirin works?

Now you should go to Acids and Bases to learn more about these two properties.

Follow the instructions and procedure on the Simulated Stomach Lab student sheet. Record your observations on the Simulated Stomach Lab Data Sheet provided by your teacher.


Knowledge Check

Answer the following questions on your Understanding What You Learned: Acid Stomach student sheet:

  1. What were some of the drawbacks to salicylic acid as a pain reliever?
  2. What are some of the benefits of aspirin?
  3. How does aspirin work?
  4. What are some strategies for reducing stomach irritation caused by aspirin?
  5. How would knowledge of the way aspirin reacts in acidic, basic, and neutral solutions help in solving the problem of stomach irritation?
  6. How has the understanding of aspirin’s molecular structure and its interaction with other chemicals in the body aided doctors in medical research?
  7. What differences, if any, did you observe in the tablets while in water? In vinegar? In baking soda solution?
  8. Enteric aspirin is designed to remain intact until it reaches the small intestine. What could you hypothesize about the pH of the small intestine?

This esheet is a part of the Acid Stomach lesson.

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Esheet Details

Grades
AAAS